Clarke signed with Dior and became the face of the Rose des Vents jewellery collection. In 2018, Dolce and Gabbana made her the brand ambassador for the fragrance The Only One. She appeared in an advertisement, which was directed by Matteo Garrone. Apart from this, Clarke is also the brand ambassador of the cosmetic and skincare brand Clinique.
In September 2011, Clarke joined hands with SMA which is a trust that raises funds for research into spinal muscular atrophy. Clarke is also the patron of Open Door, a non-profit that focuses on helping young actors gain access to drama school auditions. She also auctioned a chance to sit and watch “Game of Thrones” with her at the 2018, Sean Penn Charity Gala which raised over $120,000 benefiting the J/P HRO & Disaster Relief Organizations. She is also the ambassador to the Royal College of Nursing and wants to fight for more investment in nursing. She has launched her own charity named, SameYou. The organization aims to broaden neurorehabilitation access for the younger generation after a brain stroke or injury.
Emilia bought a mansion in Venice Beach, California for a cool $4.64 million. The house sits on a 2,817-square-foot area and features sliding glass doors, floor-to-ceiling bookcases, and a huge swimming pool. She listed this house in August of 2020 for $5 million. She reportedly purchased another 6-bedroom home in the Hampstead area of London for approximately $9 million.